Cd8a Mouse Monoclonal Antibody [Clone ID: RIV11]
CAT#: AM33387PU-N
Cd8a mouse monoclonal antibody, clone RIV11, Purified
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CNY 5,186.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | RIV11 |
Applications | ELISA, FC, IF, IHC |
Recommend Dilution | ELISA. Flow Cytometry. Immunocytochemistry. Immunohistochemistry on Frozen Sections. Recommended Positive Controls: Human lymph node, spleen and peripheral blood lymphocytes. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | This antibody derived by fusion of 653 mouse myeloma cells with splenocytes from a BALB/c mouse immunized with Human peripheral blood lymphocytes. |
Specificity | The antibody RIV11 is directed against Human CD8 and recognises all CD8 positive T-cells, thymocytes and natural killer cells. |
Formulation | PBS State: Purified State: Liquid purified IgG fraction Stabilizer: 50% Glycerol + 0.2% BSA Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | CD8 antigen, alpha chain |
Database Link | |
Background | CD8 is a 32kDa cell surface transmembrane glycoprotein expressed by most thymocytes, a subpopulation of mature peripheral blood T-cells and natural killer (NK) cells. CD8 is expressed on the cell surface as a heterodimer, comprising two distinct disulphide linked α and β polypeptide chains, or as a CD8α homodimer. The CD8 αβ heterodimer is expressed on T-cell receptor (TCR) αβ+ cytotoxic T-lymphocytes (CTL’s), whereas CD8α homodimers are expressed on TCR γδ+ T-cells, natural killer cells and a subpopulation of TCR αβ+ T-cells. The CD8 molecule functions as a co-receptor (with the T-cell receptor) as part of the antigen-recognition complex on TCRαβ+, class I MHC-restricted T cells and plays an important role in T-cell signaling. The CD8 Ig-like domain binds to the alpha-3 domain of MHC-Class. |
Synonyms | CD8 alpha chain, CD8A, MAL |
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