SNAIL (SNAI1) Mouse Monoclonal Antibody [Clone ID: AT2D5]

Specifications

Product Data
Clone Name	AT2D5
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human SNAI1 (1-264aa) purified from E. coli
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	snail family transcriptional repressor 1
Database Link	Entrez Gene 6615 Human UniProt ID O95863
Background	SNAI1, also known as Snail homolog 1, is involved in the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. This protein binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. Both SNAI1 and SLUG belong to the snail C2H2-type zinc-finger protein family. SLUG is a transcriptional repressor, involved in the generation and migration of neural crest cells. SNAI1 is expressed in mesenchymal, epithelial cell lines and highest expression in kidney.
Synonyms	SNAH, Protein snail homolog 1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adherens junction

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