PARK7 Mouse Monoclonal Antibody [Clone ID: AT1E12]

Specifications

Product Data
Clone Name	AT1E12
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Flow Cytometry. Immunocytochemistry/Immunofluorescence . Western blot / Immunoblot. The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Park7/DJ-1 (1-189aa) purified from E. coli
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Parkinsonism associated deglycase
Database Link	Entrez Gene 11315 Human UniProt ID Q99497
Background	Parkinson disease (autosomal recessive, early onset) 7, also known as PARK7/DJ-1, has been shown to interact with EFCAB6 and protein inhibitor of activated STAT2. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7. This protein belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death.
Synonyms	Oncogene DJ1, Parkinson disease protein 7
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Parkinson's disease

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