SIAH Interacting Protein (CACYBP) Mouse Monoclonal Antibody [Clone ID: AT3G8]

Specifications

Product Data
Clone Name	AT3G8
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human CACYBP (1-185aa) purified from E. coli.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	calcyclin binding protein
Database Link	Entrez Gene 27101 Human UniProt ID Q9HB71
Background	CACYBP (Calcyclin-binding protein) is primarily a nuclear protein that contains one CS domain and one SGS domain. CACYBP is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in ubiquitin E3 complexes. It also participates in the ubiquitin-mediated degradation of b-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on b-catenin protein expression and transcriptional activation of TCF/LEF.
Synonyms	Calcyclin-binding protein, S100A6BP, SIP, PNAS-107, Siah-interacting protein, S100A6-binding protein
Reference Data
Protein Pathways	Wnt signaling pathway

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