GRP78 (HSPA5) Mouse Monoclonal Antibody [Clone ID: AT3D2]

Specifications

Product Data
Clone Name	AT3D2
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human BIP (20-650aa) purified from Baculo virus.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	heat shock protein family A (Hsp70) member 5
Database Link	Entrez Gene 3309 Human UniProt ID P11021
Background	Binding immunoglobulin protein (BIP) also known as 78kDa glucose-regulated protein(GRP-78) or heat shock 70kDa protein 5(HSPA5) is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum(ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BIP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BIP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER.
Synonyms	78 kDa glucose-regulated protein, Heat shock 70 kDa protein 5, BiP
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Antigen processing and presentation, Prion diseases

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