LAR (PTPRF) (C-term, Cytopl. Dom.) Mouse Monoclonal Antibody [Clone ID: S165-38]

Specifications

Product Data
Clone Name	S165-38
Applications	IF, WB
Recommend Dilution	Western blot: 1/1000; 1μg/ml was sufficient for detection of PTPRF in 20 μg of rat brain lysate by colorimetric immunoblot using HRP conjugated secondary antibody. Immunocytochemistry.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human PTPRF protein.
Specificity	This antibody detects a 85 kDa protein (full length protein is 210 kDa – smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains. >80% identity with PTPRD and PTPRS, >50% identity with PTPRM and PTPRK.
Formulation	PBS pH 7.4, 50% Glycerol, 0.09% Sodium azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, receptor type F
Database Link	Entrez Gene 5792 Human UniProt ID P10586
Background	PTPRF or leukocyte common antigen-related protein (LAR) is a widely expressed protein tyrosine phosphatase with an extracellular receptor region that resembles a cell adhesion molecule. PTPRF removes phosphate group from β-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function (1,2,3,4).
Synonyms	PTPRF, LAR, Receptor-type tyrosine-protein phosphatase F, EC=3.1.3.48, Leukocyte common antigen related
Reference Data

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