Kcnk3 (251-411, Cytopl. Dom.) Mouse Monoclonal Antibody [Clone ID: S374-48]

Specifications

Product Data
Clone Name	S374-48
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/1000; 1 μg/ml was sufficient for detection of KCNK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody. Immunocytochemistry. Immunohistochemistry: Free floating sections, fixed in formaldehyde.
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat KCNK3 / acid-sensitive potassium channel protein TASK or TASK1.
Specificity	This antibody detects KCNK3; ~50 kDa. Does not cross-react with TASK3 / KCNK9.
Formulation	PBS pH 7.4, 50% Glycerol, 0.09% Sodium azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	potassium two pore domain channel subfamily K member 3
Database Link	Entrez Gene 29553 Rat UniProt ID O54912
Background	K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54% identity with TASK-1, but less than 30% identity with TASK-2 and other tandem pore K+ channels.
Synonyms	KCNK3, TASK, TASK1, Potassium channel subfamily K member 3
Reference Data

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