Kcnk3 (251-411, Cytopl. Dom.) Mouse Monoclonal Antibody [Clone ID: S374-48]
CAT#: AM60055PU-N
Kcnk3 (251-411, Cytopl. Dom.) mouse monoclonal antibody, clone S374-48, Purified
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CNY 5,830.00
货期*
4周
规格
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Specifications
Product Data | |
Clone Name | S374-48 |
Applications | IF, IHC, WB |
Recommend Dilution | Western blot: 1/1000; 1 μg/ml was sufficient for detection of KCNK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody. Immunocytochemistry. Immunohistochemistry: Free floating sections, fixed in formaldehyde. |
Reactivity | Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat KCNK3 / acid-sensitive potassium channel protein TASK or TASK1. |
Specificity | This antibody detects KCNK3; ~50 kDa. Does not cross-react with TASK3 / KCNK9. |
Formulation | PBS pH 7.4, 50% Glycerol, 0.09% Sodium azide State: Purified State: Liquid purified IgG fraction |
Concentration | lot specific |
Purification | Protein G chromatography |
Conjugation | Unconjugated |
Storage Condition | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Gene Name | potassium two pore domain channel subfamily K member 3 |
Database Link | |
Background | K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54% identity with TASK-1, but less than 30% identity with TASK-2 and other tandem pore K+ channels. |
Synonyms | KCNK3, TASK, TASK1, Potassium channel subfamily K member 3 |
Reference Data |
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