QK1 (QKI) (pan) Mouse Monoclonal Antibody [Clone ID: S147-6]

Specifications

Product Data
Clone Name	S147-6
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/1000; 1 μg/ml was sufficient for detection of QKI (pan) in 20 μg of rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody. Immunocytochemistry. Immunohistochemistry: Free floating sections, fixed in formaldehyde.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1-341 (full-length) of human QKI-5 (accession number Q96PU8, isoform 1) with >90% identity with QKI-6, QKI-7 and QKI-7b.
Specificity	This antibody detects a 36-38 kDa protein corresponding to the molecular weight of QKI (pan).
Formulation	PBS pH 7.4, 50% Glycerol, 0.09% Sodium azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	QKI, KH domain containing, RNA binding
Database Link	Entrez Gene 9444 Human UniProt ID Q96PU8
Background	QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients. Several isoforms are known.
Synonyms	HKQ, QK1, QK3
Reference Data

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