Ezrin (EZR) pTyr353 Rabbit Polyclonal Antibody

CAT#: AP01585PU-S

Ezrin (EZR) pTyr353 rabbit polyclonal antibody, Aff - Purified

Size: 100 ug 25 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

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Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 1/500-1/1000.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Ezrin pTyr353 protein.
Formulation Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 69 kDa
Gene Name ezrin
Background The microvillar core protein Ezrin is a tyrosine-phosphorylated protein foundin epidermal growth factor-stimulated A-431 carcinoma cells. Ezrin is phosphorylated transiently to a high level on Tyrosine residues 146 and 354. One of the sites, Tyrosine 146, lies in the amino-terminal region of homology that is common to the protein 4.1-Talin-Ezrin protein family. This tyrosine residue and its vicinal amino acids are conserved throughout the family which includes Radixin, Moesin and the two phosphotyrosine phosphatases, PTP H1 and PTP MEG. Another phosphorylation site is Tyrosine 354, which is localized within the α-helical domain of Ezrin. Cytoplasmic signaling may result in activation of Ezrin in tyrosine phosphorylation and this suggests that Ezrin has qualities that might play a role in modulation of cell shape and adhesion.
Synonyms p81, Cytovillin, Villin-2, EZR, VIL2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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