IRS1 pSer794 Rabbit Polyclonal Antibody
CAT#: AP01831PU-N
IRS1 pSer794 rabbit polyclonal antibody, Aff - Purified
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CNY 4,437.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | Immunohistochemistry on paraffin sections: 1/50-1/200. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic phosphopeptide derived from human IRS-1 around the phosphorylation site of Serine 794. |
Specificity | This antibody detects endogenous levels of IRS-1 pSer794 protein. |
Formulation | Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~132, 180 kDa |
Gene Name | insulin receptor substrate 1 |
Database Link | |
Background | Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed. |
Synonyms | Insulin receptor substrate 1, IRS-1 |
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