Fibrinogen (Oxidized), (Insoluble Fraction) Rabbit Polyclonal Antibody

CAT#: AP02137SU-N

Fibrinogen (Oxidized), (Insoluble Fraction) rabbit polyclonal antibody, Serum

Size: 20 ul 100 ul



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CNY 4,609.00


货期*
5周

规格
    • 100 ul

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Specifications

Product Data
Applications ELISA
Recommend Dilution ELISA (1/500).
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Human oxidized Fibrinogen (insoluble fraction)
Specificity This antibody detects several oxidative modifications of Fibrinogen and Lipoproteins.
Formulation State: Serum
State: Lyophilized serum
Reconstitution Method Restore in aqua bidest to initial volume.
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Background Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.
The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.
Synonyms FGA, FGB, FGG
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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