uPA (PLAU) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on Frozen sections: 1/50-1/100. Immunohistochemistry on Paraffin sections: 1/50 (Pretreatment with 0.05% Pronase E for 20 minutes).
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Purified human Urokinase plasminogen activator [uPA]
Specificity	This antibody detects Urokinase plasminogen activator. No cross reactivities obtained with tPA and PAI-2.
Formulation	State: Serum State: Lyophilized serum.
Reconstitution Method	Restore in aqua bidest to initial volume.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	plasminogen activator, urokinase
Database Link	Entrez Gene 5328 Human UniProt ID P00749
Background	Urokinase is a serine protease involved in degradation of the extracellular matrix and pos- sibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor.
Synonyms	Urokinase-type plasminogen activator, U-plasminogen activator, Urokinase
Reference Data

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