Bim (BCL2L11) pSer69/65 Rabbit Polyclonal Antibody

CAT#: AP02527PU-S

Bim (BCL2L11) pSer69/65 rabbit polyclonal antibody, Aff - Purified

Size: 50 ul 100 ul



Need it in bulk or conjugated?
Get a free quote

CNY 1,400.00


货期*
2周

规格
    • 50 ul

Product images

Specifications

Product Data
Applications IF, IHC
Recommend Dilution Immunofluorescence: 1/100-1/200.
Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen The antiserum was produced against synthesized phosphopeptide derived from Human BIM around the phosphorylation site of Serine 69 (Serine 65 in the Mouse sequence) (P-A-SP-P-G).
Specificity This antibody detects endogenous levels of BIM only when phosphorylated at Serine 69.
Formulation PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Conjugation Unconjugated
Storage Condition Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Gene Name BCL2 like 11
Background Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the Bcl2 family of proteins containing a Bcl2 homology domain 3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the Bcl2 family like Bcl2, BclxL and Bclw. Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis.
Synonyms Bcl2-L-11, BCL2L11, BIM, BimEL, BimL, BimS
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...