CTBP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IP, WB
Recommend Dilution	Immunoprecipitation. Western Blotting (Reducing conditions). Immunocytochemistry (1 μg/ml): acetone/methanol fixation.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Bacterially expressed recombinant human CtBP1.
Specificity	The polyclonal antibody reacts with CtBP1, a 49 kDa transcriptional corepressor, that plays a critical role in regulating gene expression.
Formulation	PBS, pH 7.4 with 15 mM sodium azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration	lot specific
Purification	Protein-A affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	C-terminal binding protein 1
Database Link	Entrez Gene 13016 MouseEntrez Gene 1487 Human UniProt ID Q13363
Background	C-terminal binding protein 1 / brefeldin A (BFA)-dependent ADP-ribosylation substrate (CtBP1/BARS) is a highly conserved transcriptional corepressor, that plays a critical role in regulating gene expression patterns throughout development and in oncogenesis. CtBP regulates target gene transcription, in part, via recruitment of histone deacetylases involved in gene silencing and may act to coordonate histone modifications that regulate gene expression.
Synonyms	C-terminal-binding protein 1, CTBP
Reference Data
Protein Pathways	Chronic myeloid leukemia, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway

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