PPP2R1A Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1-5 µg. Immunocytochemistry: 1/500-1/1000. Immunoprecipitation often used in combination with Ig purified anti pp2A/C to immunoprecipitate heterotrimeric pp2A.
Reactivity	Bovine, Human, Mouse, Rat
Host	Sheep
Clonality	Polyclonal
Immunogen	A peptide conjugated to KLH corresponding to amino acids 7-19 sequence (N-terminal) of PP2A/A regulatory subunit having a MW of 65kD
Specificity	This antibody recognizes Serine/Threonine Protein Phosphatase 2A/A.
Formulation	PBS pH 7.4 and 0.08% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein phosphatase 2 scaffold subunit Aalpha
Database Link	Entrez Gene 51792 MouseEntrez Gene 117281 RatEntrez Gene 5518 Human UniProt ID P30153
Background	Protein phosphatase 2A (PP2A) is the most abundant phosphatase specific for serine and threonine phosphorylation in mammalian cells. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit alpha (PPP2R1A) serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory beta subunit.
Synonyms	Protein phosphatase 2A, PP2A subunit A PR65-alpha isoform, PP2A subunit A R1-alpha isoform
Note	Predicted Molecular Weight: 65 kDa
Reference Data
Protein Families	Druggable Genome, Phosphatase, Transcription Factors
Protein Pathways	Long-term depression, Oocyte meiosis, TGF-beta signaling pathway, Tight junction, Wnt signaling pathway

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