Phosphatidic acid phosphatase type 2B (PLPP3) Rabbit Polyclonal Antibody

CAT#: AP05146PU-N

Phosphatidic acid phosphatase type 2B (PLPP3) rabbit polyclonal antibody, Purified



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CNY 7,240.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 10 - 15 µg/ml.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Unique peptide derived from the human lysophospholipid phosphatase 3 protein.
Specificity This antibody reacts to Lyosphospholipid Phosphatase (LPP) 3.
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Conjugation Unconjugated
Storage Condition The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Gene Name phospholipid phosphatase 3
Background Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently,multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8].
Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].
Synonyms PAP2-beta, PAP2B, VCIP
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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