EDG4 (LPAR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 5-10 µg/ml. Should be visualized using a high sensitivity secondary/substrate system.  Positive Control: RH7777 cells transfected with EDG4 protein.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Antibody raised against a unique synthetic peptide derived from the N-terminal of the Human EDG4 protein.
Specificity	This antibody recognizes Human EDG-4 / LPA2. Other species not tested.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulfate Precipitation
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	lysophosphatidic acid receptor 2
Database Link	Entrez Gene 9170 Human UniProt ID Q9HBW0
Background	EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.
Synonyms	EDG4, LPAR2, Ipa-2
Reference Data

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