DAP12 (TYROBP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IP, WB
Recommend Dilution	Western Blot. Immunoprecipitation: Use 2-4 µg/ml of protein lysate. Positive Control: NKp44 positive cells.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant DAP12 protein.
Specificity	This antibody is specific to DAP12.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulfate Precipitation
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	TYRO protein tyrosine kinase binding protein
Database Link	Entrez Gene 7305 Human UniProt ID O43914
Background	DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).
Synonyms	KARAP
Reference Data

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