AGPAT2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Western Blot: 5-10 µg/ml. Enzyme Immunoassay. Positive Control: Human Brain Lysate.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the LPAAT-beta protein.
Specificity	This antibody detects Lysophosphatidic Acid Acetyltransferase beta.
Formulation	Phosphate buffered saline with 0.08% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Ship on dry ice. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	1-acylglycerol-3-phosphate O-acyltransferase 2
Database Link	Entrez Gene 10555 Human UniProt ID O15120
Background	Lysophospholipid Acyltransferases (LPLATs) catalyse the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids . In addition to playing a crutial role in the synthesis of structural membrane components the LPLATs are also implicated in cellular signalling responses for cytokines, growth factors and other agonists. Cellular signalling through the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by the activation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT by interleukin 1 results in the generation of unsaturated phosphatidic acid species, that are crucial to the generation of diacylglycerol and interleukin 1 signalling. LPLATs are also involved in signalling for increased interleukin 2 synthesis through the T cell antigen receptor. Activation of T-cells via anti-CD3 stimulation has been shown to increase incorporation of polyunsaturated fatty acids into phosphatidylcholine via lysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for the sustained activation and translocation of protein kinase C.
Synonyms	1-AGP acyltransferase 2, LPAAT-beta
Reference Data

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