Netrin 1 (NTN1) Rabbit Polyclonal Antibody

CAT#: AP05263SU-N

Netrin 1 (NTN1) rabbit polyclonal antibody, Purified



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CNY 5,937.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications WB
Recommend Dilution Western blot (0.5-2 µg/ml).
Reactivity Bovine, Feline, Human, Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from the human Netrin 1 protein
Specificity This antibody detects NTN1. Tested on MDCKII cell lysates.
Formulation Phosphate buffered saline with 0.08 % sodium azide
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Gene Name netrin 1
Background Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis.
Netrin 1's main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Synonyms NTN1, NTN1L
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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