SPHK2 (Long Form) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Western blot: (1-5 µg/ml). Positive control: Jurkat lysate. ELISA.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the N-terminal extension of the Sphingosine Kinase 2-L protein
Specificity	This antibody detetcts Sphingosine Kinase 2 (Long Form).
Formulation	Phosphate buffered saline with 0.08 % sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Ligand affinity chromatography
Conjugation	Unconjugated
Storage Condition	Upon arrival, aliquot and freeze at -20°C to -70°C. Avoid repeated freezing and thawing.
Gene Name	sphingosine kinase 2
Database Link	Entrez Gene 56848 Human UniProt ID Q9NRA0
Background	The long form of sphingosine kinase 2 (Sphk2-L) is a species-specific isoform of the Sphk2 enzyme expressed in human but not in mouse. It is an N-terminal extended form of Sphk2, extended by 36 amino acids. It functions as expected, catalyzing the formation of sphingosine 1-phosphate from sphingosine, however it appears to have a decreased ability to inhibit DNA synthesis as compared to Sphk2-S (short form of Sphk2). Under normal cellular conditions, Sphk2-L does not appear to inhibit DNA synthesis, but under serum deprivation, SphK2-L translocates to the nucleus and accumlates. This accumlation may be involved in the cessation of cell proliferation or apoptosis depending on the cell type.
Synonyms	SK2, SPHK2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Metabolic pathways, Sphingolipid metabolism, VEGF signaling pathway

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