Sphingomyelin Synthase 2 (SGMS2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/400 as starting dilution. Immunohistochemistry: 1/400 as starting dilution. Positive Control: Brain, heart, kidney, liver, muscle and stomach.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the Human Sphingomyelin Synthase 2 protein
Specificity	This antibody detects Sphingomyelin Synthase 2.
Formulation	PBS, pH 7.4 State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Antigen Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	sphingomyelin synthase 2
Database Link	Entrez Gene 166929 Human UniProt ID Q8NHU3
Background	Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine and then onto ceramide. This also yields diacylglycerol as a side product. The reaction is catalysed by SM synthase, an important enzyme in the regulation of diacylglycerol and ceramide as anti- and proapoptotic stimuli. SM synthesis occurs in the lumen of the Golgi as well as on or at the cell surface. It is uncertain which SM enzyme forms are present at these differnet cellular locations. Human, mouse and Caenorhabditis elegans genomes each contain at least two different SM synthase (SMS) genes. Human SMS1 is localised to the Golgi, SMS2 resides primarily at the plasma membrane.
Synonyms	Sphingomyelin synthase 2, SMS2
Note	Predicted Molecular Weight: 42 kDa
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Metabolic pathways, Sphingolipid metabolism

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