Ceramide synthase 1 (CERS1) (Cross reacts with GDF1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot (1:400 starting dilution). Positive control: Hypothalamus.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the human Lass1 protein
Specificity	This antibody detects Lass1. Detects also GDF1.
Formulation	Phosphate buffered saline with 0.08 % sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C. Avoid repeated freezing and thawing.
Gene Name	ceramide synthase 1
Database Link	Entrez Gene 10715 Human UniProt ID P27544
Background	LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein.
Synonyms	LASS1, LAG1, UOG1, LAG1 longevity assurance homolog 1
Reference Data

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