cyclic GMP Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Succinylated cGMP conjugated to BSA
Specificity	This antibody reacts to cyclic GMP.
Formulation	State: Serum State: Liquid serum containing 0.09% Sodium Azide (NaN3)
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
Synonyms	cGMP, cyclic guanosine monophosphate
Reference Data

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