Col1a1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, R
Recommend Dilution	ELISA: 1/100-1/400. Immunofluorescence: 1/50-1/100. Radioimmunoassays. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 1/250-1/1000.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Native type I Collagen from Mouse skin.
Specificity	This antibody is specific for Mouse Collagen type I. Less than 1% cross reactivity has been observed with Mouse Collagen, types II, VI and III and Human, Chicken and Rat Collagen, type I.
Formulation	Phosphate buffered saline containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	collagen, type I, alpha 1
Database Link	Entrez Gene 12842 Mouse UniProt ID P11087
Background	Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
Synonyms	COL1A1, COL1A2, Alpha-1 type I collagen, Alpha-2 type I collagen
Reference Data

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