CTC_RS14060 Goat Polyclonal Antibody

CAT#: AP05529PU-N

CTC_RS14060 goat polyclonal antibody, Purified



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CNY 5,555.00


货期*
4周

规格
    • 1 ml

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Specifications

Product Data
Applications ELISA, WB
Recommend Dilution ELISA: 1 µg/ml.
Western Blot: 1/100-1/500.
Reactivity Clostridium tetanis
Host Goat
Clonality Polyclonal
Immunogen Tetanus Exotoxin
Specificity This antibody detects the tetanus toxin which is produced by the soil micro-organism Clostridium tetani. C. tetani infection results in its systemic growth and secretion of tetanus, which causes muscle spasms by inhibiting neurotransmitter release.
The antibody also reacts with the C-fragment (~50 kDa carboxy terminal residues 865-1315) of tetanus toxin (Emsley et al. 2000).
Formulation PBS pH 7.2
State: Purified
State: Liquid purified IgG fraction
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Background Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2.
The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.
Synonyms Clostridium tetani toxin, tetX
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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