HRK Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 2 - 5 µg/ml; detects a band of approximately 13kDa in mouse pancreas tissue lysate.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	15 amino acid peptide from near the centre of human HRK (NP_003797).
Specificity	This antibody detects Harakiri (HRK), also known as DP5.
Formulation	State: Purified State: Liquid purified IgG containing 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	harakiri, BCL2 interacting protein
Database Link	Entrez Gene 12123 MouseEntrez Gene 117271 RatEntrez Gene 8739 Human UniProt ID O00198
Background	HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.
Synonyms	Neuronal death protein DP5, BID3
Reference Data
Protein Families	Druggable Genome, Transmembrane

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