Stxbp1 pSer515 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:1000; detects a band/s of approximately 65kDa in rat cortex cell lysates.
Reactivity	Bovine, Canine, Chicken, Human, Monkey, Mouse, Rat, Xenopus
Host	Rabbit
Clonality	Polyclonal
Immunogen	Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18.
Specificity	This antibody recognises Munc-18 phosphorylated at serine 515.
Formulation	10mM Hepes pH7.5 containing 0.09% Sodium Azide (NaN3), 50% Glycerol and 0.01% Bovine Serum Albumin State: Purified State: Liquid purified IgG
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	syntaxin binding protein 1
Database Link	Entrez Gene 25558 Rat UniProt ID P61765
Background	Munc-18 is a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.
Synonyms	Unc-18 homolog, Unc-18-1, Unc-18A, N-Sec1, Syntaxin-binding protein 1
Reference Data

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