carabin (TBC1D10C) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1 - 2 µg/ml; detects a band of approximately 55kDa in human spleen tissue cell lysates. Immunohistochemistry on paraffin sections (requires antigen retrieval).
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 17 amino acid peptide from near the amino terminus of human Carabin.
Specificity	This antibody recognises Carabin, also known as TBC1 domain family member 10C (TBC1D10C), a 50 kDa protein belonging to the TBC1 domain family of proteins. This antibody does not cross react with either TBC1D10A or TBC1D10B.
Formulation	Phosphate buffered saline containing 0.02% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	TBC1 domain family member 10C
Database Link	Entrez Gene 374403 Human UniProt ID Q8IV04
Background	Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes.
Synonyms	TBC1D10C
Reference Data

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