GJA1 pSer368 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:1000; detects a band of approximately 43kDa in rat hippocampus cell lysates.
Reactivity	Bovine, Canine, Chicken, Guinea Pig, Human, Mouse, Rat, Zebrafish
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368
Specificity	This antibody specifically recognises 43kDa Connexin43, when phosphorylated at Ser368.
Formulation	10mM HEPES, pH7.5 containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin, 50% Glycerol State: Purified State: Liquid purified Ig
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	gap junction protein alpha 1
Database Link	Entrez Gene 2697 Human UniProt ID P17302
Background	Connexin43 (CX43) allows for the exchange of solutions between neighbouring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. Studies suggest that a decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C (PKC). A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumours and peritumoural reactive astrocytes (3).
Synonyms	Gap junction alpha-1 protein, Connexin-43, GJAL
Reference Data

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