CARD6 Rabbit Polyclonal Antibody
CAT#: AP06035PU-N
CARD6 rabbit polyclonal antibody, Aff - Purified
Need it in bulk or conjugated?
Get a free quote
CNY 4,640.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Immunofluorescence: 1/50-1/200. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to the N-terminual of Human CARD6. |
Specificity | This antibody detects endogenous levels of CARD6/CIN protein (region surrounding Ala2). |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Predicted Protein Size | ~ 116 kDa |
Gene Name | caspase recruitment domain family member 6 |
Database Link | |
Background | Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1–3) and the caspase-associated recruitment domain (CARD) proteins, CARD 6, CARD 8-12 and CARD 14. CARD 6 is a 311 amino acid protein that associates with microtubules and acts as a selective mediator of NFκB activation. CARD 6 is structurally and functionally related to the superfamily of interferon (IFN)-inducible GTPases, a group that comprises host defense proteins which mediate cell-autonomous immunity. RICK, the receptorinteracting protein (RIP)-like interacting caspase-like apoptosis regulatory protein kinase, interacts with CARD 6 and targets it to aggresomes, regions of the cell where protein aggregates collect. |
Synonyms | CINCIN1 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...