MST1 (+MST2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500-1/2000. Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 150-200 of Human MST1.
Specificity	This antibody detects endogenous levels of MST1/2 protein. (region surrounding Meth178)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 65 kDa
Gene Name	macrophage stimulating 1
Database Link	Entrez Gene 15235 MouseEntrez Gene 4485 Human UniProt ID P26927
Background	Sterile-20 (STE20) is a serine/threonine kinase in Saccharomyces cerevisiae that is involved in relaying signals from G protein coupled receptors to cytosolic MAP kinase cascades. Mammalian protein kinases that display sequence similarity to STE20 are divided into two groups, the PAK subfamily and the GCK subfamily. The PAK subfamily members contain a C-terminal catalytic domain and an N-terminal regulatory domain with a p21Rac/Cdc42-binding site, and these kinases can activate both p38MAPK and JNK. The GCK subfamily members contain a C-terminal regulatory domain and an Nterminal catalytic domain, and they have diverse roles in many pathways, including the activation of ERK< JNK, p38 MAPK, and caspase-3. The mammalian STE20-like kinases (MST kinases, also known as Ksr proteins) are members of the GCK subfamily.
Synonyms	MST1, D3F15S2, DNF15S2, HGFL, Macrophage-stimulating protein, Hepatocyte growth factor-like protein, MSP
Reference Data
Protein Families	Druggable Genome

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