14-3-3 zeta (YWHAZ) Rabbit Polyclonal Antibody
CAT#: AP06623PU-N
14-3-3 zeta (YWHAZ) rabbit polyclonal antibody, Aff - Purified
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CNY 1,999.00
CNY 4,640.00
货期*
2周
规格
Cited in 2 publications. |
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 200-250 of Human 14-3-3 ζ. |
Specificity | This antibody detects endogenous levels of 14-3-3 ζ/δ protein. (region surrounding Trp228) |
Formulation | Phosphate Buffered Saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~28 kDa |
Gene Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta |
Database Link | |
Background | 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities. |
Synonyms | YWHAZ, KCIP-1 |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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Proteomic analysis of differentially expressed proteins in vitamin C-treated AGS cells
,Nagappan A, Park HS, Park KI, Kim JA, Hong GE, Kang SR, Zhang J, Kim EH, Lee WS, Won CK, Kim GS,
BMC Biochem.
,PubMed ID 24067024
[YWHAZ]
|
Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo-/- mice
,Nagappan A, Park HS, Park KI, Hong GE, Yumnam S, Lee HJ, Kim MK, Kim EH, Lee WS, Lee WJ, Cho MJ, Lee WK, Won CK, Cho JH, Kim GS,
Chem. Biol. Interact.
,PubMed ID 24035909
[YWHAZ]
|
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