GPR37 (N-term extracell. dom.) Rabbit Polyclonal Antibody

CAT#: AP06819PU-N

GPR37 (N-term extracell. dom.) rabbit polyclonal antibody, Aff - Purified



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CNY 5,654.00


货期*
6周

规格
    • 50 ug

Product images

Specifications

Product Data
Applications ELISA, IHC
Recommend Dilution ELISA.
Immunohistochemistry on Paraffin Sections: 3 µg/ml.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen GPR37 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37.
Specificity This antibody detects N-terminal extracellular domain of human PAEL Receptor (GPR37).
Formulation PBS containing 0.09% sodium azide as preservative
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Immunoaffinity Chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
Avoid repeated freezing and thawing.
Gene Name G protein-coupled receptor 37
Background GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death.
Synonyms G-protein coupled receptor 37, PAELR, ETBR-LP-1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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