DKK1 (C-term) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/128000. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1 - 3 µg/ml.
Reactivity	Human, Bovine, Canine, Equine, Goat, Monkey, Mouse, Porcine
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from the C-terminus of human DKK1 (NP_036374.1)
Specificity	This antibody reacts with C Terminus of DKK1.
Formulation	Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	dickkopf WNT signaling pathway inhibitor 1
Database Link	Entrez Gene 22943 Human UniProt ID O94907
Background	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Synonyms	DKK1, DKK-1, Dickkopf-related protein 1, SK
Reference Data

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