Angiotensin Converting Enzyme 2 (ACE2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 0.5 - 2 µg/ml.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within aa 180-230 of ACE2.
Specificity	This antibody reacts with a peptide corresponding to amino acids near the center of ACE2.
Formulation	PBS containing 0.02% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing.
Gene Name	angiotensin I converting enzyme 2
Database Link	Entrez Gene 59272 Human UniProt ID Q9BYF1
Background	Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology . In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Synonyms	Angiotensin-converting enzyme 2
Note	Family: Protease. Subfamily: Metallopeptidase M2.
Reference Data

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