CARD9 (521-536) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunocytochemistry. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 0.5 - 1 µg/ml.
Reactivity	Human, Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide from aa 521-536 of human CARD9
Specificity	This antibody detects aa 521-536 of CARD9.
Formulation	PBS containing 0.02% Sodium Azide as preservative State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing.
Gene Name	caspase recruitment domain family member 9
Database Link	Entrez Gene 64170 Human UniProt ID Q9H257
Background	Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of BCL-10. CARD9 associates with BCL-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-kB. CARD9 is an upstream activator of BCL-10 and NF-kB signaling.
Synonyms	hCARD9
Reference Data

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