PD1 (PDCD1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunohistochemistry on FFPE-Sections: ~2.5 - 5 µg/ml (after heat induced antigen retrieval in pH 6.0 citrate buffer). Immunofluorescence. Western Blot. Expect a band at ~ 47 kD in size. THP-1 cell lysate can be used as positive control.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to 16 Amino Acid from near the carboxy terminus of Human PDCD1.
Specificity	This antibody is specific to CD279/PDCD1
Formulation	PBS containing 0.02% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for up to 3 months or at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	programmed cell death 1
Database Link	Entrez Gene 5133 Human UniProt ID Q15116
Background	This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Synonyms	Protein PD-1, hPD-1, PDCD1
Reference Data

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