HOX11 (TLX1) (306-318) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1 - 3 µg/ml.
Reactivity	Human, Mouse, Rat, Bovine, Bat, Canine, Chicken, Equine, Hamster, Monkey, Rabbit
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide sequence corresponding to acids amino acids 306-318 of human HOX11
Specificity	This antibody recognizes Homeobox Protein Hox-11 (TLX1) at aa 306-318.
Formulation	PBS containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	T-cell leukemia homeobox 1
Database Link	Entrez Gene 3195 Human UniProt ID P31314
Background	HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
Synonyms	TLX-1, T-cell leukemia homeobox protein 1, HOX11, Hox-11, TCL3, TCL-3
Reference Data

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