Col18a1 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1 µg/ml. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1 µg/ml.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to C-terminal residues of Mouse Col18a1 (Collagen alpha1(XVIII) chain precursor, contains: Endostatin)
Specificity	This antibody recognizes Collagen XVIII Alpha 1 (COL18A1) at C-term.
Formulation	PBS containing 0.01% Sodium Azide as preservative and 50% Glycerol as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	collagen, type XVIII, alpha 1
Database Link	Entrez Gene 12822 Mouse UniProt ID P39061
Background	COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Defects in COL18A1 are a cause of Knobloch syndrome (KNO). KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
Synonyms	COL18A1, Endostatin, KNO1
Reference Data

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