ATG7 (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunocytochemistry. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1 - 2 µg/ml.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to 17 amino acids peptide from near the amino terminus of human APG7.
Specificity	This antibody recognizes Ubiquitin Activating Enzyme E1-like Protein (GSA7/ATG7).
Formulation	PBS containing 0.02% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	autophagy related 7
Database Link	Entrez Gene 10533 Human UniProt ID O95352
Background	Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by Target of rapamycin (TOR) via phosphorylation of autophagy protein APG1. APG7 is a member of the autophagy family of proteins and was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog. In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.
Synonyms	APG7-like, Autophagy-related protein 7
Reference Data

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