Kcnc1 pSer503 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Dot Blot: 1/1000. Western blot: 1/1000. Immunofluorescence. Immunohistochemistry on Frozen Sections: 1/1000.
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of KCNC1 conjugated to keyhole limpet hemocyanin (KLH).
Specificity	This antibody recognizes the ~100k KCNC1 (Kv3.1) protein phosphorylated at Ser503 in Rat brain extracts.
Formulation	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol. State: Aff - Purified State: Liquid purified Ig fraction.
Purification	Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	potassium voltage-gated channel subfamily C member 1
Database Link	Entrez Gene 25327 Rat UniProt ID P25122
Background	Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
Synonyms	Potassium voltage-gated channel subfamily C member 1, Voltage-gated potassium channel subunit Kv3.1, Kv4, NGK2
Reference Data

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