MIF (103-115) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/128000. Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 0.01 - 0.03 µg/ml.
Reactivity	Human, Mouse, Rat, Monkey
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from C-terminus of Human MIF
Specificity	This antibody recognizes Macrophage Migration Inhibitory Factor (MIF) at aa 103-115.
Formulation	Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% Sodium Azide as preservative State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Database Link	Entrez Gene 4282 Human UniProt ID P14174
Background	MIF is a proinflammatory cytokine involved in many inflammatory reactions and disorders. MIF (macrophage migration inhibitory factor) was one of the first cytokines to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity. MIF is involved in both autoimmune disorders and tumorigenesis.
Synonyms	Macrophage migration inhibitory factor, Phenylpyruvate tautomerase, Glycosylation-inhibiting factor, GLIF, MMIF
Reference Data

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