KCNN2 Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	Peptide ELISA: Detection Limit: 1/64000. Western blot: 0.3-1 µg/ml. Approx 70kDa and 23kDa bands observed in Human Liver lysates (calculated MW of 63.8kDa according to NP_067627.2 and of 26.3kDa according to NP_740721.1). Immunohistochemistry on Paraffin Sections: 1-2 µg/ml. In Paraffin Embedded Humam Thyroid Gland shows membranous staining in the epithelial cells.
Reactivity	Bovine, Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the Internal region of the protein sequence according to NP_067627.2; NP_740721.1.
Specificity	This antibody is expected to recognize both isoforms of KCNN2 (NP_067627.2; NP_740721.1).
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	potassium calcium-activated channel subfamily N member 2
Database Link	Entrez Gene 54262 RatEntrez Gene 140492 MouseEntrez Gene 3781 Human UniProt ID Q9H2S1
Background	A widely expressed protein forming a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Synonyms	KCNN2, SK2
Reference Data
Protein Families	Druggable Genome, Ion Channels: Potassium, Transmembrane

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