CFTR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IP, WB
Recommend Dilution	ELISA: 1/2000-1/32000. Western Blot: 1/500-1/1000. Immunofluorescence. Immunoprecipitation.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from Cter domain of human CFTR protein.
Specificity	Reacts with Human 168 kDa CFTR.
Formulation	0.1M Tris 0.1M Glycine, 2% Sucrose State: Purified State: Lyophilized purified antibody Preservative: None
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	cystic fibrosis transmembrane conductance regulator
Database Link	Entrez Gene 1080 Human UniProt ID P13569
Background	Cystic Fibrosis (CF) is a common lethal genetic disease characterized by chronic bronchopulmonary disease, elevated sweat electrolytes and insufficient pancreatic function. CF is caused by mutations of the CFTR gene, which encodes the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR protein is a cAMP-activated chloride channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 which results in abnormal chloride transport. CFTR is structurally similar to multi-drug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Synonyms	Cystic fibrosis transmembrane conductance regulator
Reference Data

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