CFTR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IP, WB
Recommend Dilution	ELISA: 1/2000-1/32000. Western Blot: 1/500-1/1000. Immunofluorescence. Immunoprecipitation.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptides derived from C-terminal domain of Human CFTR protein
Specificity	This antibody reacts with human 168 kDa CFTR.
Formulation	Tris 0,1M, glycine 0,1M, sucrose 2% State: Serum State: Lyophilized serum Preservative: None
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer Avoid repeated freezing and thawing.
Gene Name	cystic fibrosis transmembrane conductance regulator
Database Link	Entrez Gene 1080 Human UniProt ID P13569
Background	CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Synonyms	Cystic fibrosis transmembrane conductance regulator
Reference Data

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