Aromatase (CYP19A1) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/1000. Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 453~485 amino acids from the C-terminal region of Human CYP19A1.
Specificity	This antibody detects Aromatase (CYP19A1) at C-term.
Formulation	PBS with 0.09% (W/V) Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cytochrome P450 family 19 subfamily A member 1
Database Link	Entrez Gene 1588 Human UniProt ID P11511
Background	CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in the gene encoding CYP19A1 can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.
Synonyms	Cytochrome P450 19A1, CYPXIX, Estrogen synthetase, P450AROM, CYP19A1, ARO1, CYAR, CYP19
Note	Calculated Molecular Weight: 57883 Da
Reference Data

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