Eph receptor B2 (EPHB2) Rabbit Polyclonal Antibody

CAT#: AP14298PU-N

Eph receptor B2 (EPHB2) rabbit polyclonal antibody, Purified



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CNY 6,160.00


货期*
5周

规格
    • 400 ul

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution ELISA: 1/1,000.
Western blotting: 1/50 - 1/100.
Immunohistochemistry: 1/10 - 1/50.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a recombinant human EphB2 protein.
Specificity This antibody reacts to EphB2.
Formulation PBS with 0.09% (W/V) sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name EPH receptor B2
Background Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ligand-activated form of EphB2, which belongs to the Tyr family of protein kinases, interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. It binds RASGAP through the juxtamembrane tyrosines residues, and also interacts with PRKCABP and GRIP1 This type I membrane protein is expressed in brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. It is preferentially expressed in fetal brain. This protein contains putatively 2 fibronectin type III domains and 1 sterile alpha motif (SAM) domain.
Synonyms Ephrin type-B receptor 2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5, NY-REN-47
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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