Cathepsin K (CTSK) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Western blot: 1:1000. Immunohistochemistry on formalin-fixed, paraffin-embedded sections: 1:10 - 1:50. Flow Cytometry: 1:10 - 1:50.
Reactivity	Bovine, Human, Monkey, Porcine, Rabbit
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between aa 207-27 from the Center region of human CTSK.
Specificity	This antibody detects Cathepsin K at Center.
Formulation	PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Purified through Protein A column followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cathepsin K
Database Link	Entrez Gene 1513 Human UniProt ID P43235
Background	The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.
Synonyms	Cathepsin O, Cathepsin X, Cathepsin O2, CTSK, CTSO, CTSO2
Note	Molecular weight: 36966 Da
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Lysosome

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