PTGIS (C-term) Rabbit Polyclonal Antibody
CAT#: AP17980PU-N
PTGIS (C-term) rabbit polyclonal antibody, Purified
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CNY 6,160.00
货期*
5周
规格
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | ELISA: 1/1,000. Western blotting: 1/1,000. Immunohistochemistry on Paraffin Sections: 1/50-1/100. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 472-500 amino acids from the C-terminal region of Human CYP8A1. |
Specificity | This antibody recognizes PTGIS. |
Formulation | PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide |
Concentration | lot specific |
Purification | Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | 57104 kDa |
Gene Name | prostaglandin I2 (prostacyclin) synthase |
Database Link | |
Background | CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. |
Synonyms | Prostacyclin Synthase, CYP8, CYP8A1 |
Reference Data | |
Protein Families | Druggable Genome, P450, Transmembrane |
Protein Pathways | Arachidonic acid metabolism, Metabolic pathways |
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